In season mode, the player plays a General Manager (GM) for ten years (game time), unless the player runs out of money by the beginning of the year. These cards are 'yes,' 'no,' 'challenge,' or 'Marvin.' Also, the player is given Fate Cards to make a decision. The character can play any position such as a starting pitcher, reliever, closer, or fielder. The player must have to improve the character by practicing, studying, earning money in a part-time job, dating, and playing baseball games.

The character has three years to impress a scout to make it to the minor leagues. (Note: Success mode is the mode which Power Pro Series create original players). Unlike the Japanese installments, My Life mode is not included in this installment, but it has an ability editor which Japanese version never had, due to the importance and popularity of success mode in Japan. The player will train their character in numerous games while dealing with other social situations such as the character's academics, teammate Marvin, and gaining a part-time job. The story-based Success Mode, which has been a regular element in the Japanese series (main series) since the third release, mixes traditional role playing elements with baseball scenarios, following the player's character as he starts from a college baseball player with the goal of becoming a Major League player. Players may also play exhibition mode with two players, or can watch a game against two teams with the computer controlling both teams and take the role of a spectator. There are options for a day game or night game, number of innings, what stadium to play at, lineup selection etc. In this mode, players may play a baseball game against a Major League team. Maximum playtime is 10 years, or the when team points run out and the player loses (game over). The player has control over all the aspects of the team, including training players, purchasing better equipment, and trading players between teams. Within the former, the player takes the role of a General Manager of a Major League Baseball team, with the goal of winning the World Series. The game contains over a dozen gameplay modes, including a Season Mode and a Success Mode. Gameplay in MLB Power Pros features 'easy pick-up and play mechanics'.

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